Vassilis Ithakisios studied painting at the School of Fine Art, Athens between 1896 and 1899 under Nikiforos Lytras and Georgios Roilos.

He later continued his studies in Antwerp and in 1901 settled down in Smyrna where he worked successfully until the fall of the city in 1922.

After living briefly in Athens, he then became a recluse, living in a cave on Mount Olympus for twenty years, after which he returned to Athens.

His great love of nature drove him to travel and explore rural Greece. His main subject matter was the Greek landscape but he also worked on portraiture. His work, like that of his peers, is defined by academism, whilst also sensitively depicting atmospheric variations, creating a poetic feeling.

His work is found in many public and private collections, notably: The National Gallery Greece, The Athens Municipal Gallery, The Leventis Gallery, The Averoff Gallery, The Koutlides Collection and The National Bank of Greece collection.